Data-driven mechanistic analysis of digital therapeutic–assisted training and evaluation of personalized protocol effects in children with attention deficit/hyperactivity disorder

IntroductionDigital therapeutics (DTx) for children with ADHD have gained attention as adjunctive interventions to pharmacotherapy; however, evidence remains limited regarding the mechanisms underlying training performance decline and the clinical effectiveness of performance data–driven personalized protocols. This study aimed to identify the core mechanisms of performance decline using digital training performance data and to compare the effects of a mechanism-based personalized protocol with