Frontiers in Psychiatry | New and Recent Articles

BackgroundMajor depressive disorder (MDD) is recognized as a pressing global public health burden. However, its molecular mechanisms remain incompletely understood.MethodsIn this study, an integrative analysis of transcriptome datasets from the GEO database was conducted. GEO2R and the R programming language were used to identify differentially expressed genes (DEGs) related to oxidative stress a…

BackgroundProlonged Grief Disorder (PGD) is a psychiatric diagnosis with significant implications for individuals and society. Familiarity with its diagnostic criteria and recommended interventions is essential for early detection and effective treatment. As aging naturally involves multiple losses, older adults are at distinct risk of developing PGD, a condition associated with psychological and…

Background and objectivesThe diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is an important imaging biomarker for assessing glymphatic system function. However, the cortical and white matter metrics associated with changes in the DTI-ALPS index have not been fully elucidated, and the relationship between these two types of metrics remains controversial.MethodsWe com…

IntroductionResidents have a high risk of burnout during the training period. The COVID-19 pandemic has had a great impact on work conditions and health of medical residents. We therefore estimated the prevalence of post-pandemic burnout and perceived health, and their relationship with psychosocial factors, stress profile, and job satisfaction, as well as the pre-post pandemic changes.MethodsWe …

Depression is characterized by high prevalence, high recurrence, high disability and high mortality, which seriously affects people’s work and life. Among various behavioral biomarkers, speech-based features have gained increasing attention in depression detection due to their non-invasive nature, affordability, and rich capacity for conveying affective states. However, conventional depression re…

This randomized controlled study examined the efficacy of a culturally adapted parent-mediated intervention for parents and young children with autism (n = 45) from low-resource households (ClinicalTrials.gov Identifier: NCT04505488). Families from these settings are often left out of autism intervention studies and arguably have unique needs not considered in autism intervention work. Parent/chi…

BackgroundDeath wishes and end-of-life legislation are increasingly relevant in ageing societies, where demographic shifts and evolving legal frameworks appear to raise complex ethical and clinical challenges.SummaryWishes to die among older adults are complex and not limited to mental illness or terminal illness. Although depression and demoralization are common, evidence suggests that many olde…

IntroductionDigital therapeutics (DTx) for children with ADHD have gained attention as adjunctive interventions to pharmacotherapy; however, evidence remains limited regarding the mechanisms underlying training performance decline and the clinical effectiveness of performance data–driven personalized protocols. This study aimed to identify the core mechanisms of performance decline using digital …

IntroductionTraditional pharmaco-electroencephalography (EEG) studies have mainly examined the effects of psychotropic medications at the level of individual drugs or broad drug classes, limiting biological specificity and clinical translation. This study aimed to determine whether modeling EEG spectral power changes according to the engagement of distinct neurotransmitter systems provides a more…

Extrapyramidal syndrome (EPS) refers to a group of movement disorders resulting from dysfunction of the extrapyramidal system (motor pathways outside the pyramidal tract). Among the various pathogenic factors of EPS, chronic or long-term use of antipsychotic drugs (APDs) is worth special note. This article aims to provide a comprehensive review on the application of phytomedicines in preventing a…

ObjectiveTo develop a multimodal deep learning–based classification model for adolescent bipolar depression (ABD) with verbal auditory hallucinations (AVHs).MethodsA retrospective analysis was conducted on 47 untreated ABD patients within 30 days, between January 2024 and August 2025. Comprehensive clinical data were collected, including sex, age, age at onset, years of education, and the presenc…

IntroductionChronic fatigue syndrome (CFS) is a complex disorder of unknown etiology, characterized by persistent fatigue unrelieved by rest and accompanied by cognitive dysfunction. While dysregulated cytokines are implicated in CFS pathogenesis, the role of anti-inflammatory transforming growth factor β1 (TGF-β1) remains poorly defined.MethodsThis study investigated central and peripheral TGF-β…

Tiletamine is a dissociative anesthetic used in veterinary medicine and has recently emerged as a potential illicit additive in e-cigarettes after regulation of etomidate. However, reports of chronic tiletamine-containing e-cigarette use remain scarce. We report the case of a 22-year-old man who developed progressive gait instability, dysarthria, choking on drinking, hand tremor, emotional instab…

This study aimed to examine the fit of a structural equation model relating selected job demands and job resources to burnout and perceptions of educational coexistence among Chilean education personnel. A total of 710 workers from this sector (administrators, teachers, and teaching assistants) participated. Structural equation modeling (SEM) was conducted using robust maximum likelihood estimati…

BackgroundAttentional bias modification (ABM) training is employed to modulate attentional bias and alleviate clinical symptoms in obsessive-compulsive disorder (OCD) patients. This study aimed to develop a novel, ecologically valid ABM paradigm based on virtual reality (VR). The intent was to enhance the efficacy of traditional computerized ABM and to preliminarily examine its feasibility in pat…

BackgroundSubacute combined degeneration (SCD) of the spinal cord is a progressive neurological disorder caused by vitamin B12 deficiency. When initial symptoms present as nonspecific fatigue, dizziness, and affective distress, the condition is frequently misattributed to primary psychiatric disorders. This “diagnostic overshadowing” leads to critical delays in administering definitive therapy, r…

BackgroundAttention-deficit/hyperactivity disorder (ADHD), a common neurodevelopmental condition, often requires treatment with stimulants such as methylphenidate and nonstimulants such as atomoxetine. Despite their effectiveness, medication-related side effects, adherence and symptom control issues have increased the interest in alternative therapies, especially herbal medicine. However, existin…