Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a serious global health threat associated with both nosocomial and community-acquired infections. The reduced efficacy of meropenem due to diverse resistance mechanisms emphasizes the need to investigate genetic determinants and their association with meropenem susceptibility, which is explored in this study. We have performed pan-genome analysis and genome-wide association studies on 350 K. pneumoniae genomes with corresponding antimicrobial