HHV-8 genotypes and clinical features in Kaposi sarcoma and primary effusion lymphoma in people living with HIV in Salvador, Brazil

IntroductionHuman herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi sarcoma (KS) and primary effusion lymphoma (PEL), important causes of morbidity and mortality among people living with HIV (PLWH). The highly polymorphic ORF-K1 region is commonly used for HHV-8 genotyping and phylogenetic analysis. We investigated the distribution of HHV-8 genotypes and their clinical correlates among PLWH diagnosed with KS or PEL in Salvador, Brazil.MethodsBetween 2022 and 2025, biological specimens from