Unveiling the unique gut microbial signatures in colorectal adenomas: establishment and validation of a cross-kingdom microbiome predictive model

BackgroundColorectal adenoma (CA), the main precancerous lesion of colorectal cancer (CRC), originates in approximately 85–90% of CRC cases. With increasing demands for early diagnosis and treatment, gut microbiome research has become a forefront area. While numerous studies have shown that gut bacteria are closely related to the development of colorectal adenomas and cancer, research on viruses, archaea, and fungi is limited.MethodsFrom January 2019 to January 2024, this study collected 296 fec