cancer

Researchers created a DIA-MS atlas of 13,609 proteins across 2,856 samples from fetal, healthy adult, paired non-tumor, and tumor tissues. The resource maps tissue-specific protein patterns, cancer-associated changes, organ-specific drug-toxicity signals, and candidate therapeutic targets.

Researchers have identified a gene that appears to balance a powerful evolutionary trade-off, boosting growth and reproductive success early in life while carrying hidden costs later on. The biological processes that help build a healthy young body may also sow the seeds of aging and cancer. Researchers have now identified a gene that appears to [...]

PDAC is dominated by KRAS signaling. To reveal these hidden vulnerabilities, we turned to pancreatic acinar cell carcinoma (ACC), a rare KRAS-independent pancreatic malignancy that offers a unique biological window beyond KRAS-driven oncogenesis.

Nature Communications, Published online: 20 June 2026; doi:10.1038/s41467-026-74452-8 Excessive Reactive oxygen species (ROS) production by neutrophils drives necrotizing inflammation of small blood vessels in Anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). However, the mechanism responsible for the dysregulated ROS production remains uncharacterized. Here, the authors re…

People usually think of doctors and nurses when they think about preventing cancer. Yet some of the most effective health messages may come from places that have nothing to do with hospitals. A new study suggests that one of those places could be your neighborhood barbershop. Researchers at the University of Portsmouth have found that […] The post Could Your Haircut Become a Skin Cancer Check? ap…

Researchers have found that a genetic mutation associated with a rare group of blood cancers does not always result in development of the disease.

IntroductionThe gastric microbiota affects tumor development and treatment response, yet the characteristics and interactions of mucosal bacteria and fungi in advanced gastric cancer (AGC) remain unclear.MethodsHere we analyzed 177 mucosal samples (88 peritumoral and 89 tumoral) from 91 AGC patients in Northwest China using shotgun metagenomic sequencing.ResultsMetaPhlAn4 and Kaiju were used to a…

The gut microbiome constitutes a complex and metabolically active ecosystem that exerts profound effects on host physiology through the production of diverse small-molecule metabolites. Increasing evidence indicates that microbiome-derived metabolites function as a critical bridge linking microbial dysbiosis with tumor initiation, progression, immune modulation, and therapeutic responsiveness. Al…

Jaye Gardiner is an assistant professor of biology at Tufts University, where she focuses on the extracellular matrix (ECM) around cancerous tumors. Being first-generation as both an American and a college graduate, Gardiner didn’t have the easiest path there. But starting in high school, several mentors, including a chemistry teacher who made the periodic table fun, helped to guide her to a care…

Most genetic testing of cancer cells focuses on individual point mutations, single spots in the genome where a base pair has changed, gone missing or been added. But these mutations don’t account for all cancers. There are many other structural variations in which large chunks of the chromosome undergo some kind of dramatic change and result in malignancies. “Now we realize that not just individu…

BackgroundColorectal adenoma (CA), the main precancerous lesion of colorectal cancer (CRC), originates in approximately 85–90% of CRC cases. With increasing demands for early diagnosis and treatment, gut microbiome research has become a forefront area. While numerous studies have shown that gut bacteria are closely related to the development of colorectal adenomas and cancer, research on viruses,…

This tip sheet from Sylvester Comprehensive Cancer Center, at the University of Miami Miller School of Medicine, features several cancer-related story ideas including paradoxical mesothelioma findings, a new immunotherapy drug for relapsed multiple myeloma, how gliomas evolve after treatment and more.

Wang, Liang and colleagues show that the TEAD1 transcription factor can organize micrometre-sized nuclear biomolecular condensates independently of active transcription. TEAD1 condensates may act as depots for excess TEAD1.

Nature Cell Biology, Published online: 15 June 2026; doi:10.1038/s41556-026-01991-z Diao, Zou et al. demonstrate that activation of the integrated stress response drives lineage dedifferentiation and tumour progression in lung adenocarcinoma, associated with aberrant mitochondrial function and metabolic fitness.

A molecular geneticist at Montana State University has discovered a cellular process once believed impossible by scientists – the creation of the amino acid cysteine within a living cell when the cell's primary systems to do so fail. The discovery may one day lead to new cancer treatments.

Nature Cell Biology, Published online: 12 June 2026; doi:10.1038/s41556-026-01980-2 Bassot, Violy, Gorka, Cigalotto and colleagues identify ERO1a as a mitochondria-associated membrane protein that regulates calcium flux and mitochondria bioenergetics, which may be potentially targeted to inhibit glioblastoma growth in vivo.

A team of Johns Hopkins Bloomberg School of Public Health researchers has discovered large droplets of proteins known as condensates near inactive chromosome regions within the cell nucleus that are a feature of some cancer cells and may hold clues for better anticancer strategies.