Nature Immunology, Published online: 22 June 2026; doi:10.1038/s41590-026-02537-z Kurup and colleagues follow Plasmodium-specific memory Treg cells in humans and mice. Individuals with higher frequencies of memory Treg cells exhibited better protection after reinfection due to plasticity of Treg cells to become TFH cell-like and promote protective antibody responses.
Memory regulatory T cells reprogram into protective T FH cell-like effectors in recurrent malaria
Samarchith P. Kurup