Nature Immunology

Nature Immunology, Published online: 09 September 2026; doi:10.1038/s41590-026-02643-y Granucci and colleagues identify microbial adhesion to myeloid cells as a critical initiating event that precedes engagement of pattern recognition receptors.

Nature Immunology, Published online: 09 September 2026; doi:10.1038/s41590-026-02658-5 Myeloid cell immunophenotyping in women and functional studies in mice indicated that monocytes contribute to both inflammation and tissue remodeling in the uterus and dynamically regulate tissue homeostasis throughout the reproductive cycle. Dysregulation of monocyte function was associated with uterine fibros…

Nature Immunology, Published online: 09 September 2026; doi:10.1038/s41590-026-02664-7 We found that antiviral CD8+ T cells can deputize the local innate immune system to destroy tumors. Thus, CD8+ T cells can kill by proxy, which has ramifications for cancer treatment and general mechanisms of CD8+ T cell function.

Nature Immunology, Published online: 09 September 2026; doi:10.1038/s41590-026-02644-x Jiang and colleagues show that the adaptor protein AMBRA1 binds NLRP3 to destabilize the closed, inactive conformation of NLRP3 and facilitate binding of ATP and transition to the active state of NLRP3.

Nature Immunology, Published online: 08 September 2026; doi:10.1038/s41590-026-02642-z Here the authors show that T cell activation within tumors triggers tumor clearance that is independent of tumor antigen recognition and occurs via a paracrine mechanism involving effector cytokines, nitric oxide, leukocyte recruitment and innate immune cells.

Nature Immunology, Published online: 08 September 2026; doi:10.1038/s41590-026-02657-6 The EMBO workshop ‘Pathogen Immunity and Signaling’ was held from 8 to 11 June 2026 in Leiden, the Netherlands, bringing together 175 participants from 25 countries to discuss the latest advances in antimicrobial immune defense.

Nature Immunology, Published online: 08 September 2026; doi:10.1038/s41590-026-02659-4 The Zeb2 −165-kb enhancer is not a simple genetic switch but a regulatory crossroads where transcription factors compete to calibrate lineage decisions and shape immune cell diversity.

Nature Immunology, Published online: 08 September 2026; doi:10.1038/s41590-026-02651-y Mann and colleagues reveal key roles for monocytes in replenishing the subsets of uterine macrophages involved in tissue remodeling and inflammation. These processes maintain tissue homeostasis in healthy reproductive cycles, but are disrupted in reproductive disease.

Nature Immunology, Published online: 08 September 2026; doi:10.1038/s41590-026-02650-z Chimeric antigen receptors (CARs) have revolutionized engineered cell therapies for cancer. Impressive anti-tumor effects have now been achieved by fitting CARs onto fused macrophage–neutrophil hybrid syncytial, with a promising outlook for stand-alone and combination therapies.

Nature Immunology, Published online: 01 September 2026; doi:10.1038/s41590-026-02669-2 Author Correction: Peyer’s patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22

Nature Immunology, Published online: 01 September 2026; doi:10.1038/s41590-026-02635-y Natural killer (NK) cells leave distinct footprints on the HIV reservoir, leading to a smaller HIV reservoir size in individuals carrying the HLA-C2 allele. HIV escapes NK cell-mediated immunity through mutations in the viral proteins Vpu, Gag and Env.

Nature Immunology, Published online: 01 September 2026; doi:10.1038/s41590-026-02637-w HIV reservoir cells are traditionally considered invisible to host immune responses due to viral latency. This work challenges this view by demonstrating that HIV persistence during long-term antiretroviral therapy is strongly influenced by KIR2DL1-educated NK cells.

Nature Immunology, Published online: 31 August 2026; doi:10.1038/s41590-026-02638-9 Kim and colleagues describe a population of monocyte-derived lung galectin-1+ myeloid cells that support the generation and maintenance of lung-resident memory CD8+ T cells following influenza virus infection.

Nature Immunology, Published online: 31 August 2026; doi:10.1038/s41590-026-02639-8 Ivashkiv discusses recent advances in rheumatoid arthritis research using state-of-the-art single-cell and spatial transcriptomics and organoid systems, and discusses how these insights can be leveraged to further delineate disease biology and therapeutic opportunities.

Nature Immunology, Published online: 31 August 2026; doi:10.1038/s41590-026-02645-w A population of inflammatory monocytes differentiates into persistent lung-resident Gal-1+ myeloid cells that colocalize with and support the long-term maintenance and recall responses of influenza virus-induced tissue-resident memory CD8+ T cells.

Nature Immunology, Published online: 26 August 2026; doi:10.1038/s41590-026-02662-9 Author Correction: Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth

Nature Immunology, Published online: 25 August 2026; doi:10.1038/s41590-026-02647-8 Aging by impaired efferocytosis

Nature Immunology, Published online: 25 August 2026; doi:10.1038/s41590-026-02648-7 B reg cells to the rescue

Nature Immunology, Published online: 25 August 2026; doi:10.1038/s41590-026-02649-6 Microglia effects

Nature Immunology, Published online: 25 August 2026; doi:10.1038/s41590-026-02646-9 Rear entry pyroptosis inhibition