Nature Immunology

Nature Immunology, Published online: 22 June 2026; doi:10.1038/s41590-026-02591-7 Author Correction: The transcriptional coactivator TAZ regulates reciprocal differentiation of T H 17 cells and T reg cells

Nature Immunology, Published online: 22 June 2026; doi:10.1038/s41590-026-02548-w Asymmetric cell division is thought to affect chimeric antigen receptor (CAR) T cell efficacy owing to distinct CAR T daughter cell effector and memory T cell fates. Here the authors show how the costimulatory domain of the CAR T cell can affect this process.

Nature Immunology, Published online: 22 June 2026; doi:10.1038/s41590-026-02537-z Kurup and colleagues follow Plasmodium-specific memory Treg cells in humans and mice. Individuals with higher frequencies of memory Treg cells exhibited better protection after reinfection due to plasticity of Treg cells to become TFH cell-like and promote protective antibody responses.

Nature Immunology, Published online: 22 June 2026; doi:10.1038/s41590-026-02564-w Memory regulatory T cells can shed their suppressive identity and become T follicular helper-like effector cells during recurrent malaria, identifying an unexpected mechanism that links immune regulation with protective humoral immunity.

Nature Immunology, Published online: 22 June 2026; doi:10.1038/s41590-026-02559-7 Asymmetric cell division can result in functionally distinct CAR-T cells. Data now indicate that this asymmetry is an early ‘program selector’ that can explain why 4-1BBζ CAR-T cells preferentially generate durable memory progeny whereas CD28ζ CAR-T cells skew toward short-lived effector fates.

Nature Immunology, Published online: 22 June 2026; doi:10.1038/s41590-026-02543-1 On 11–14 March 2026, the Vaccine Innovation Forum World 2026 (VIF World 2026) was held in Shanghai, China.

Nature Immunology, Published online: 19 June 2026; doi:10.1038/s41590-026-02566-8 Taniuchi and Brown and colleagues report that the Runx–CBFβ transcription factor complex plays a crucial role in the development of intestinal RORγt+ antigen-presenting cells, which are required to promote tolerance to food and gut commensal microorganisms.

Nature Immunology, Published online: 18 June 2026; doi:10.1038/s41590-026-02546-y Regulatory T cells are responsible for suppressing inflammation, yet they fail to do so in rheumatoid arthritis. We show that signals in the local tissue environment can drive these cells into either protective or dysfunctional states.

Nature Immunology, Published online: 16 June 2026; doi:10.1038/s41590-026-02540-4 Brenner and colleagues identify two predominant tissue-resident Treg cell subsets (suppressive CD25hiCXCR6pos and dysfunctional CD25loAREGpos) in synovial joints from patients with rheumatoid arthritis. These functionally divergent Treg cell subsets are shaped by local microenvironmental cues supplied by macrophages…

Nature Immunology, Published online: 16 June 2026; doi:10.1038/s41590-026-02571-x B cells display a range of effector and memory phenotypes, antibody isotypes and affinities. We show that during malaria parasite infection, individual, activated clones commonly combine early, class-switch recombination, clonal expansion, effector fate bifurcation and somatic hypermutation to rapidly diversify in v…

Nature Immunology, Published online: 15 June 2026; doi:10.1038/s41590-026-02568-6 Some patients with pyoderma gangrenosum harbor a mutation (R57C) in OTULIN that disrupts the interaction between OTULIN and LUBAC leading to hyperactivation in monocytes and enhanced susceptibility of keratinocytes to TNF-induced, caspase-dependent cell death. One patient treated with anti-TNF therapy showed clinica…

Nature Immunology, Published online: 15 June 2026; doi:10.1038/s41590-026-02563-x Here, the authors conduct integrated multiomics analysis of B cell activation, differentiation and diversification responses to malaria infection and provide a graphical user interface for readers to mine these data.

Nature Immunology, Published online: 15 June 2026; doi:10.1038/s41590-026-02569-5 This study compares the humoral response of individuals who received inactivated influenza vaccines to that of individuals who received an mRNA-based quadrivalent influenza vaccine. The mRNA-based vaccine induced prolonged germinal center responses, more antibodies and increased numbers of memory B cells.

Nature Immunology, Published online: 12 June 2026; doi:10.1038/s41590-026-02562-y The identification of an alveolar epithelial-like subset of medullary thymic epithelial cells (mTECs) reveals a key mechanism that orchestrates mTEC heterogeneity, thereby maintaining central immune tolerance.

Nature Immunology, Published online: 10 June 2026; doi:10.1038/s41590-026-02576-6 Retraction Note: Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells

Nature Immunology, Published online: 10 June 2026; doi:10.1038/s41590-026-02574-8 Author Correction: Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity

Nature Immunology, Published online: 08 June 2026; doi:10.1038/s41590-026-02542-2 Davidson et al. map the cellular and structural composition of developing joints and identify fibroblast populations that may predispose joints to inflammatory arthritis.

Nature Immunology, Published online: 02 June 2026; doi:10.1038/s41590-026-02552-0 Fed T cells

Nature Immunology, Published online: 02 June 2026; doi:10.1038/s41590-026-02550-2 Stromal immunology in Sjögren disease

Nature Immunology, Published online: 02 June 2026; doi:10.1038/s41590-026-02553-z Affinity maturation of AAN-I-IFNs