Fate induction through asymmetric T cell division is modulated by chimeric antigen receptor costimulatory domains

Nature Immunology, Published online: 22 June 2026; doi:10.1038/s41590-026-02548-w Asymmetric cell division is thought to affect chimeric antigen receptor (CAR) T cell efficacy owing to distinct CAR T daughter cell effector and memory T cell fates. Here the authors show how the costimulatory domain of the CAR T cell can affect this process.