Design of dual-effect molecules based on lysosome-targeting strategy: a mechanistic study on synergistic inhibition of ewing sarcoma and coronaviruses

IntroductionAddressing clinical challenges such as the toxicity of conventional chemotherapy and viral drug resistance, this study proposes and validates an innovative “host organelle-targeting” strategy. By disrupting the function of host lysosomes—an organelle commonly exploited by both tumors and viruses—we aim to develop novel therapeutic agents with dual antitumor and antiviral activity.MethodsWe rationally designed and synthesized the target compound 3-chloro-4-(4-(diethylamino)butoxy)benz