The heart powers a busy highway of arteries and vessels, providing a constant to-and-fro passage for blood. During a heart attack, this passage becomes blocked, usually when a blood clot forms on plaque in a coronary artery and cuts off blood flow to the heart muscle. A study published in Science found that the heart […]
In a model of abnormal eye vessel growth, removing ZEB1 made vessels grow more and become leakier. The study suggests ZEB1 controls vessel quality, not just vessel growth.
IntroductionThe abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are significant pathological factors contributing to atherosclerosis (AS). Neferine (Nef) is a dibenzylisoquinoline alkaloid isolated from the Nelumbo nucifera. Our previous studies revealed that Nef has a good pharmacological effect on AS by inhibiting macrophage glycolytic reprogramming. However, the re…
BackgroundAberrant VSMC proliferation, migration, and phenotypic switching drive vascular remodeling. Oxidative stress is pivotal, but effective antioxidants are limited.MethodsA catalase-loaded nanocapsule (CAT-nc) was developed for sustained ROS scavenging in Ang II-induced VSMCs.ResultsCAT-nc reduced ROS, inhibited proliferation/migration, restored contractile phenotype via PTEN reactivation a…
Researchers have developed a new platform that can replicate different types of blood vessel structures. Blood vessels are less like straight pipes and more like a crowded city road map, with turns, forks, and sudden choke points that can change how traffic moves. For a long time, many lab built vessel models skipped that complexity [...]
UVA Author: Gael Genet Citation: Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerdà P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK. Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation. 2024 Mar 19;149(12):944-962. doi: 10.1161/CIRCULATIONAHA.122.0629…
UVA Author: Karen Hirschi Citation: Marziano C, Genet G, Hirschi KK. Vascular endothelial cell specification in health and disease. Angiogenesis. 2021;24(2):213-236. doi:10.1007/s10456-021-09785-7 DOI: https://link.springer.com/article/10.1007/s10456-021-09785-7 Pub-Med Number: 33844116 There are two vascular networks in mammals that coordinately function as the main supply and drainage systems o…
Alghanem AF, Abello J , Maurer JM, Kumar A, Ta CM, Gunasekar SK, Fatima U, Kang C, Xie L, Adeola O, Riker M, Elliot-Hudson M, Minerath RA, Grueter CE, Mullins RF, Stratman AN , and Sah R
Stratman AN , Burns MC, Farrelly OM, Davis AE, Li W, Pham VN, Castranova D, Yano JJ, Goddard LM, Nguyen O, Galanternik MV, Bolan TJ, Kahn ML, Mukouyama Y, and Weinstein BM
