clinical-trials

Background: Chronic myeloid leukemia is commonly treated with tyrosine kinase inhibitors, and numerous clinical trials have been conducted globally. However, the overall registration distribution, trial development patterns, and public availability of trial results remain unclear. This study aimed to map the global landscape of such trials and assess the public availability of their results.Metho…

You probably don't think twice about putting on your socks – until your back makes...

[BigHat Biosciences] The first patient has been dosed in BigHat Biosciences' Phase 1 clinical trial evaluating BHB810, a novel, potentially best-in-class Cadherin-17 (CDH17)-directed VHH-Fc antibody-drug conjugate for the treatment of gastric cancer and other advanced gastrointestinal malignancies.

When months-old Cristofer was diagnosed with a rare, severe neurodegenerative disease, world-class research and clinical trials at U of U Health gave him and his family new hope for the future.

arXiv:2609.01202v1 Announce Type: cross Abstract: Clinical trials are essential for advancing cancer care and drug development, but many fail because of insufficient patient enrollment. While there is growing interest in using AI to support patient recruitment, existing systems largely perform eligibility assessment alone and have rarely been evaluated in real-world oncology workflows. Here we pr…

Patient centricity is often most visible at the point of trial participation—through recruitment strategies, patient communications, travel support, and other services designed to facilitate engagement. But by the time these elements are introduced, many of the decisions that shape the patient experience have already been made.  Protocol requirements, site strategy, visit schedules, procedures, e…

When added to standard chemotherapy, a clinical version of the dietary supplement L-glutamine improved survival in an early-phase trial of patients with advanced pancreatic cancer. The study, led by Cedars-Sinai Health Sciences University investigators, was published in Nature Cancer.

Sophos IRB, an independent central Institutional Review Board, today announced its launch as the first independent central IRB company dedicated to oncology, introducing a specialized model for the ethical and regulatory review of oncology clinical research.

Nature Communications, Published online: 31 August 2026; doi:10.1038/s41467-026-77041-x Anti-HER2 antibody-drug conjugates (ADCs) have been approved for patients with Hormone Receptor positive (HR + ), HER2-low metastatic breast cancer. Here, the authors present a phase II interventional clinical trial evaluating the anti-HER2 ADC SHR-A1811 as neoadjuvant monotherapy in patients with HR + HER2-lo…

Histotripsy was cleared by the US FDA for the treatment of primary and metastatic liver tumors almost three years ago. Researchers sought to gather an early national snapshot of its use for this indication.

Tufts Center for the Study of Drug Development celebrates 50 years of research and data informing improvements in pharmaceutical development and regulatory policy

About half of patients with Duchenne muscular dystrophy (DMD), a life-limiting disease with limited therapeutic options and no cure, have elevated body mass indexes (BMI) in the overweight or obesity range due to a combination of factors includin..

The U.S. Food and Drug Administration (FDA) has approved daraxonrasib, an oral multi-selective RAS(ON) inhibitor, for adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or are not candidates for multiagent systemic therapy. The approval is based primarily on the results from the pivotal randomized phase 3 RASolute 302 trial comparing daraxonrasi…

Here’s what recruitment has to get right so willing patients reach a trial ready to enroll them. Every September, World Alzheimer's Day asks the world to remember the people behind a diagnosis and the families beside them. This year, the 2026 World Alzheimer Report puts clinical trials at the center of that conversation (Alzheimer's Disease International, 2026). For families living with dementia …

The U.S. Food and Drug Administration (FDA) has approved daraxonrasib, an oral multi-selective RAS(ON) inhibitor, for adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or are not candidates for multiagent systemic therapy. The approval is based primarily on the results from the pivotal randomized phase 3 RASolute 302 trial comparing daraxonrasi…

The Cardiovascular Research Foundation (CRF) announced the late-breaking clinical trials and science selected for presentation at TCT 2026, the annual scientific symposium of CRF and the world's premier educational meeting specializing in interventional cardiovascular medicine. This year's conference will take place October 31-November 3 at the San Diego Convention Center bringing together leadin…