clinical-trials

Scientists comment on an update from the Medicines and Healthcare Products Regulatory Agency (MHRA) on the PATHWAYS trial of puberty … read more

Background/ObjectivesWe have previously demonstrated that the natural alkaloid Cepharanthine (Ceph) reduces renal injury in streptozotocin (STZ)-induced insulin-deficient diabetic rats via antioxidant and anti-inflammatory mechanisms. However, the hypoglycemic mechanism of Ceph remains unclear. We hypothesize that Ceph reduces blood glucose in STZ-induced insulin-deficient diabetic rats via resto…

IntroductionChronic alcohol exposure is associated with increased vulnerability to acute respiratory distress syndrome (ARDS), and emerging evidence suggests that this susceptibility extends to the severe respiratory manifestations of COVID- 19. The SARS-CoV-2 Spike Protein S1 subunit (S1SP) can independently trigger robust inflammatory and vascular injury responses in the lung, and our prior wor…

BackgroundPostoperative depression is a common complication following non-small cell lung cancer (NSCLC) resection, which adversely affects quality of life and may impede long-term survival. Modified Sini Powder (MSNP), a modified traditional Chinese medicine formula derived from classical Sini Powder, has been used in clinical practice to alleviate depressive symptoms. However, comprehensive evi…

ObjectiveTo characterize the distribution of voriconazole (VRC) trough concentrations (Ctrough), identify factors associated with VRC exposure in HIV-infected patients complicated by invasive fungal disease (IFD), and determine the Ctrough threshold associated with an increased risk of adverse drug reactions (ADRs).MethodsA retrospective study was conducted at the First Hospital of Changsha from …

Gastric cardia cancer is a biologically heterogeneous malignancy arising at the gastroesophageal junction that is, the upper opening of the stomach rather than the heart. It develops along an inflammation-metaplasia-dysplasia-carcinoma sequence and remains clinically challenging because early lesions are often occult and advanced disease is shaped by a treatment-resistant tumor microenvironment. …

IntroductionItaly represents one of major hubs for clinical research in Europe, nevertheless comprehensive long-term analyses of its clinical trial landscape under evolving regulatory frameworks remain limited. This study examines the trends of clinical trials submitted to the Italian Medicines Agency (AIFA) over a 10-year period, evaluating the impact of the COVID-19 pandemic, the transition to …

BackgroundCurrent clinical guidelines recommend either muscarinic receptor antagonists or β3-adrenoceptor agonists for overactive bladder (OAB) treatment. These recommendations, however, are primarily based on short-term (12-week) clinical trials, leaving a critical gap in evidence regarding their long-term (≥1 year) efficacy and safety. Moreover, the long-term evidence synthesized here is limite…

Critical Path Institute® (C-Path), through its Type 1 Diabetes Consortium, today reaffirmed its commitment to strengthening the regulatory-science and evidence infrastructure needed to enable the next phase of therapeutic innovation across multiple stages of type 1 diabetes (T1D).

IntroductionPancreatic cancer remains a leading cause of death with poor prognosis. Current standard chemotherapies offer limited survival benefits, and no standard treatment exists for patients failing two lines of therapy. Preclinical evidence suggests that targeting MNK and VEGFR pathways can remodel the immunosuppressive tumor microenvironment and enhance immunotherapy efficacy. This study ev…

Once-daily oral elecoglipron produced dose-dependent weight loss in adults with obesity or overweight without diabetes, with mean reductions reaching 10.5% at 26 weeks and 11.8% at 36 weeks in the highest-dose weekly-titration group. The phase 2 trial found no evidence of a weight-loss plateau by 36 weeks, while gastrointestinal adverse events were common but generally manageable.

A Phase 1-2 rare rheumatology program achieved all startup milestones ahead of schedule, enrolled eight healthy volunteer cohorts back-to-back on time, and navigated a fundamentally different enrollment landscape when transitioning to patients. The team managed this while adapting to frequent strategy changes and maintaining close sponsor governance across multiple geographies.

A landmark clinical trial published in the prestigious New England Journal of Medicine found that tranexamic acid reduced transfusions across major surgeries without increasing the risk of dangerous blood clots.

BackgroundAnthracyclines are key for acute myeloid leukemia (AML) but carry serious side effects. This study identifies their side effects across drugs and patient populations using the FDA Adverse Event Reporting System (FAERS).Materials and methodsWe analyzed 1,079 AML cases and 3,622 adverse events (AEs) from FAERS (2004–2024). Disproportionality analyses (PRR, ROR, BCPNN, MGPS) detected AE si…

Aim of the StudyTo observe the efficacy and safety of CQE in rapidly alleviating inflammatory activity in UC.Materials and MethodsCQE extracts were analyzed by UHPLC–Q Exactive Orbitrap–HRMS. This study used a self-controlled design before and after treatment. A total of 114 UC patients were included and treated with traditional rectal enema administration of CQE. Among them, 107 patients complet…

AimsInfliximab (IFX) is widely used for treating Crohn’s disease (CD), but a significant proportion of patients experience primary non-response or loss of response. Early prediction of IFX efficacy is crucial to avoid ineffective treatment, adverse effects, and financial burden. The aim of this study was to develop a stacking model using routine clinical data to predict IFX clinical response.Meth…

IntroductionPharmacogenomics (PGx) is an emerging medicines optimization tool that may support efficacy and safety relating to antipsychotic prescribing. Despite growing drug-gene evidence linked to antipsychotic response, how PGx could be implemented within Early Intervention in Psychosis (EIP) services, including the views of staff, service users, and carers remains underexplored.MethodsSemi-st…

The University of Chicago Medicine Comprehensive Cancer Center (UCCCC) will remain one of the nation's leading sites for cancer clinical research, thanks to a new, six-year, $5 million grant from the National Cancer Institute (NCI).

Scientific Reports, Published online: 09 June 2026; doi:10.1038/s41598-026-56099-z Correction: Effects of DRG pulsed radiofrequency parameters on the clinical outcome for battered sensory never syndrome: a prospective, triple-blind, randomized controlled trial

In a clinical trial, an experimental antibody reduced lean-mass loss in people on a GLP-1 drug. Whether that improves health is unclear.