alzheimers

Scientific Reports, Published online: 19 June 2026; doi:10.1038/s41598-026-55865-3 Extension of overlap measures for Multi-Class Biomarker Evaluation in Alzheimer's Disease

Nelson et al. present a detailed biomolecular study of how the APOE-R136S mutation protects against Alzheimer’s disease (AD) in mice and in patient-derived cells. Lots of data on glial contributions and transcriptomic changes. I see this as an excellent target for gene therapies aiming to combat AD. So do the folks at Lexeo Therapeutics (an […]

Scientists may have uncovered a hidden trigger behind Alzheimer’s disease. Instead of plaques being the root cause, amyloid beta appears to interfere with tau, a protein that helps keep neurons functioning properly. This disruption could set off the damage that eventually leads to the disease’s most recognizable brain changes.

Alzheimer’s disease gradually steals memories, independence, and quality of life from millions of people worldwide. Despite decades of research, scientists still struggle to find treatments that can stop the disease from progressing. Most available medications provide only modest benefits and cannot fully prevent the loss of brain cells that characterizes the condition. A new study […] The post S…

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease for which disease-modifying therapies remain limited. Despite extensive efforts targeting amyloid-β and tau, these approaches have not translated into clear clinical benefit, underscoring the need for a more integrated understanding of AD pathogenesis. This narrative review summarizes recent advances in the molecular mechanisms u…

A large genetic study suggests that Alzheimer’s disease and Parkinson’s disease are linked to the body’s metabolism in strikingly different ways. That may help explain why metabolic treatments, including GLP-1-based drugs, do not necessarily have the same effects across neurodegenerative diseases.

Most copper in the brain is a problem. It piles up in the wrong places, drives the oxidative chaos that kills neurons, and for years the going wisdom in Alzheimer’s research has been to strip it out New! Sign up for our email newsletter on Substack. New! Sign up for our email newsletter on Substack. Most copper in the brain is a problem. It piles up in the wrong places, drives the oxidative chaos…

Bill Ritter, anchor on WABC since 2001, said he’s stepping down but will continue to report on the disease A longtime New York City television news anchor has announced his sudden retirement from the airwaves after revealing that he has the early signs of Alzheimer’s disease. Bill Ritter, a veteran of ABC New York station WABC, has presented the main evening news in New York since 2001 and become…

Dementia remains stubbornly resistant to treatment and devastating for millions of people worldwide. Scientists have...

Researchers have uncovered a previously underappreciated mechanism involved in Alzheimer’s disease and developed a compound that interrupts it. For decades, Alzheimer’s research has largely focused on amyloid plaques and tau tangles, the protein abnormalities that accumulate in the brain as the disease progresses. Yet despite billions of dollars in research and numerous drug development efforts, …

New research has found an association between taking glucosamine, a popular over-the-counter supplement used for joint pain, and a higher likelihood of progressing from mild cognitive impairment to Alzheimer's disease.

Alzheimer's disease is most commonly diagnosed in older adults, but that doesn't mean the condition...

A new study suggests that subtle changes in the brain’s immune cells could help explain why some people remain mentally sharp despite Alzheimer’s pathology. For decades, Alzheimer’s research has focused on the buildup of amyloid plaques and tau tangles, the two hallmark features of the disease. Yet a puzzling reality has continued to challenge scientists: [...]

An estimated 7.4 million Americans aged 65 and older are now living with Alzheimer's disease, according to the Alzheimer's Association's 2026 Alzheimer's Disease Facts and Figures report, and that number is projected to climb to nearly 13 million by 2050.

Alzheimer’s disease is one of the most challenging health problems facing the world today. It gradually destroys memory, thinking skills, and the ability to carry out everyday activities. Millions of people are living with the disease, and the number is expected to rise as populations age. Although scientists have learned a great deal about Alzheimer’s […] The post Can Immune System Trigger Alzhe…

Scientists have uncovered an early brain mechanism that may help explain why people carrying the APOE4 gene face a higher risk of Alzheimer’s disease. For millions of people who carry the APOE4 gene, the strongest known genetic risk factor for Alzheimer’s disease, changes in brain activity may start years before memory problems become noticeable. Researchers [...]

Scientists discovered how some people maintain sharp minds despite having Alzheimer's-related brain damage. A recent study identifies a specific genetic signature and introduces a mouse model that recreates this protective state to guide future treatments.

Almost 50 more genes have been flagged as being linked to Alzheimer’s, along with changes in activity in crucial cells that disappear as dementia progresses

The Lancet World Report examines why regulators in the US, UK, and Europe have reached different decisions on new amyloid-targeting Alzheimer’s drugs despite evidence that they can modestly slow clinical decline. It highlights the unresolved balance among benefits, safety risks, costs, access, and the need for broader, earlier, and more patient-centered treatment strategies.