A new mouse study indicates the common artificial sweetener aspartame could exacerbate stroke-related brain damage. The sweetener suppresses protective cellular signals and increases oxidative stress, leading to higher rates of brain cell death.
Thoracic aortic aneurysms involving the root and ascending aorta progressively enlarge and can lead to life-threatening acute aortic dissections, collectively termed thoracic aortic disease (TAD). Oxidative stress due to an excess of reactive oxygen species (ROS) has been implicated in TAD pathogenesis by promoting vascular inflammation, extracellular matrix degradation, and smooth muscle cell ap…
Neurological disorders, including depression, cognitive impairment, and neurodegenerative diseases, are closely associated with oxidative stress, apoptotic neuronal loss, and impaired neuronal differentiation. Polyamine derivatives from natural products have emerged as potential neuroprotective agents, although their mechanisms remain incompletely understood. In this study, three polyamine compou…
ObjectiveThis study aimed to investigate the antioxidant, antihyperlipidemic, antihypercholesterolemic, and hepatoprotective properties of Acacia nilotica (A. nilotica) pod extracts in male albino Wistar rats.MethodsA. nilotica pod extracts (ANPE) were prepared using ethanol, methanol, acetone, and distilled water. Antioxidant properties were evaluated by determining total phenolic content (TPC),…
IntroductionPlant-derived exosome-like nanoparticles (PDENs) have emerged as bioactive nanostructures capable of transferring molecular cargos across species; however, their mechanistic roles in mammalian stress-responsive signaling remain incompletely defined. In this study, we investigated the effects of green tea (Camellia sinensis (L.) Kuntze [Theaceae])–derived exosome-like nanoparticles (Gt…
Biomedical Engineering & Biosciences - Juniper Publishers Abstract Aging is a process that brings many changes in the body and free radicals are increasingly remarked responsible for most of these changes. A theory which is called "free radical theory of aging" assumes that accumulation of reactive oxygen species (ROS) caused aging. Additionally, aging is a multifactorial process and this process…
Reading Time: 3 minutes MND Association-funded researchers, Prof Dame Kay Davies and Dr Peter Oliver, both based at the University of Oxford, have identified the oxidation resistance 1 (OXR1) The post Oxidation Resistance 1 – tackling oxidative stress appeared first on MND Research Blog .
