Nature Reviews Drug Discovery

Nature Reviews Drug Discovery, Published online: 07 September 2026; doi:10.1038/s41573-026-01514-3 There are currently no approved therapies for sarcopenia, the age-related loss of skeletal muscle mass and strength. This Review discusses advances in understanding of the cellular, molecular and metabolic mechanisms driving muscle wasting with ageing, while assessing emerging therapeutic approaches…

Nature Reviews Drug Discovery, Published online: 07 September 2026; doi:10.1038/d41573-026-00148-9 Edith Heard, CEO of the Francis Crick Institute, discusses the need to break down biomedical boundaries.

Nature Reviews Drug Discovery, Published online: 04 September 2026; doi:10.1038/d41573-026-00147-w Newest glue degrader nabs multiple myeloma approval

Nature Reviews Drug Discovery, Published online: 02 September 2026; doi:10.1038/d41573-026-00146-x Click chemistry platform enhances ADC tumour targeting

Nature Reviews Drug Discovery, Published online: 01 September 2026; doi:10.1038/s41573-026-01513-4 Solute carrier transporters are critical for maintaining central nervous system homeostasis, and their dysregulation is implicated in neurological diseases. This Review discusses the roles of solute carriers in neurodegenerative diseases, autism spectrum disorders and epilepsy, highlighting therapeu…

Nature Reviews Drug Discovery, Published online: 28 August 2026; doi:10.1038/d41573-026-00140-3 The landscape for in vivo CAR T cell therapies

Nature Reviews Drug Discovery, Published online: 28 August 2026; doi:10.1038/d41573-026-00141-2 Viral protease-initiated pyroptosis

Nature Reviews Drug Discovery, Published online: 28 August 2026; doi:10.1038/d41573-026-00142-1 CAR-T cell therapy for multiple sclerosis

Nature Reviews Drug Discovery, Published online: 28 August 2026; doi:10.1038/d41573-026-00143-0 A metabolically activated molecular glue

Nature Reviews Drug Discovery, Published online: 28 August 2026; doi:10.1038/d41573-026-00144-z Serotonin receptor agonist suppresses colorectal cancer

Nature Reviews Drug Discovery, Published online: 27 August 2026; doi:10.1038/d41573-026-00145-y RevMed’s RAS inhibitor gains landmark FDA approval for pancreatic cancer

Nature Reviews Drug Discovery, Published online: 26 August 2026; doi:10.1038/d41573-026-00139-w Small molecule boosts Parkinson disease treatment

Nature Reviews Drug Discovery, Published online: 24 August 2026; doi:10.1038/s41573-026-01509-0 Drug discovery for psychiatric disorders is a slow and challenging process, driven in part by reliance on symptom-based diagnostic criteria that fail to capture the underlying disease biology. In their Perspective, Etkin and co-authors suggest a framework for a precision psychiatry approach, drawing on…

Nature Reviews Drug Discovery, Published online: 24 August 2026; doi:10.1038/s41573-026-01517-0 Transcriptional CDKs coordinate gene expression throughout the transcription cycle and are increasingly recognized as therapeutic targets. This Review examines their roles in cancer-associated transcriptional dysregulation and highlights emerging strategies to modulate transcriptional CDKs for therapeu…

Nature Reviews Drug Discovery, Published online: 12 August 2026; doi:10.1038/d41573-026-00136-z Oncolytic virus nabs FDA approval

Nature Reviews Drug Discovery, Published online: 10 August 2026; doi:10.1038/d41573-026-00135-0 As Takeda’s oveporexton (Orzeyful) becomes a first-in-class treatment for narcolepsy type 1, industry eyes broader indications for orexin receptor agonists.

Nature Reviews Drug Discovery, Published online: 07 August 2026; doi:10.1038/s41573-026-01496-2 Applications of artificial intelligence (AI) in drug discovery have attracted high interest in recent years, but evidence for clinically relevant impact so far is limited. This Perspective discusses potential reasons, including an insufficient focus on clinical translation during model development and …

Nature Reviews Drug Discovery, Published online: 06 August 2026; doi:10.1038/d41573-026-00134-1 Lilly spends US$2.8 billion on psychedelic drugs for mental health

Nature Reviews Drug Discovery, Published online: 06 August 2026; doi:10.1038/d41573-026-00133-2 First dual BAFF and APRIL inhibitor nabs FDA approval

Nature Reviews Drug Discovery, Published online: 05 August 2026; doi:10.1038/d41573-026-00132-3 Expanding the molecular glue target space