Nature Reviews Drug Discovery

Nature Reviews Drug Discovery, Published online: 18 June 2026; doi:10.1038/d41573-026-00107-4 Multispecific T-cell engagers that bind three or more targets on cancer and immune cells promise to address the shortcomings of their bispecific predecessors.

Nature Reviews Drug Discovery, Published online: 18 June 2026; doi:10.1038/d41573-026-00106-5 A growing pipeline of multispecific antibody therapies are in clinical trials, showcasing novel biological effects as well as potential improvements over multi-agent cocktails.

Nature Reviews Drug Discovery, Published online: 18 June 2026; doi:10.1038/d41573-026-00105-6 New antibiotic targets novel ribosomal site

Nature Reviews Drug Discovery, Published online: 12 June 2026; doi:10.1038/d41573-026-00099-1 David Reese, Amgen’s inaugural Chief Technology Officer, discusses how inconspicuous AI achievements stand to transform drug discovery.

Nature Reviews Drug Discovery, Published online: 12 June 2026; doi:10.1038/d41573-026-00103-8 Upcoming FDA approval decisions in Q3 2026

Nature Reviews Drug Discovery, Published online: 12 June 2026; doi:10.1038/d41573-026-00102-9 Novel drug targets in 2025

Nature Reviews Drug Discovery, Published online: 11 June 2026; doi:10.1038/d41573-026-00100-x First CD123-targeted ADC secures FDA approval for rare blood cancer

Nature Reviews Drug Discovery, Published online: 11 June 2026; doi:10.1038/d41573-026-00101-w Antiviral peptide nabs FDA approval for hepatitis delta virus infection

Nature Reviews Drug Discovery, Published online: 10 June 2026; doi:10.1038/d41573-026-00098-2 Advancing ferroptosis-targeted therapies

Nature Reviews Drug Discovery, Published online: 10 June 2026; doi:10.1038/d41573-026-00097-3 Evolution of the psoriasis therapy landscape

Nature Reviews Drug Discovery, Published online: 09 June 2026; doi:10.1038/d41573-026-00082-w Analysis of a decade of post-authorisation studies for medicines approved by the EMA

Nature Reviews Drug Discovery, Published online: 09 June 2026; doi:10.1038/d41573-026-00096-4 Implantable hydrogel encapsulates ‘living therapeutics’

Nature Reviews Drug Discovery, Published online: 08 June 2026; doi:10.1038/s41573-026-01473-9 Reply to ‘Stimulating medicines repurposing in the EU: a pilot project’

Nature Reviews Drug Discovery, Published online: 08 June 2026; doi:10.1038/d41573-026-00095-5 ASO sustains microglial neural repair activity

Nature Reviews Drug Discovery, Published online: 04 June 2026; doi:10.1038/d41573-026-00094-6 The ongoing outbreak of Bundibugyo Ebola virus disease in the Democratic Republic of the Congo highlights the urgent need to bridge therapeutic gaps for non-Zaire ebolaviruses by prioritizing and accelerating development and evaluation of broadly applicable and species-specific filovirus countermeasures.

Nature Reviews Drug Discovery, Published online: 03 June 2026; doi:10.1038/s41573-026-01459-7 mRNA technology is being applied to develop a new generation of therapies for rare and common diseases. This Review discusses insights from clinical studies on mRNA-based therapeutics, including enzyme replacement therapies, cancer immunotherapies, genome-modifying therapies and immune cell reprogramming…

Nature Reviews Drug Discovery, Published online: 03 June 2026; doi:10.1038/d41573-026-00093-7 Informing HIV vaccine design

Nature Reviews Drug Discovery, Published online: 03 June 2026; doi:10.1038/d41573-026-00090-w Inhibiting lactate transport reduces lung fibrosis

Nature Reviews Drug Discovery, Published online: 03 June 2026; doi:10.1038/d41573-026-00091-9 Understanding Ras inhibitor resistance

Nature Reviews Drug Discovery, Published online: 03 June 2026; doi:10.1038/d41573-026-00092-8 Inhibiting Nipah virus