inflammation

A new study reveals that two different inflammatory proteins in the blood signal separate types of brain damage. Both distinct pathways ultimately converge to fuel Alzheimer's-related tau tangles, brain shrinkage, and memory decline in older adults.

Dysfunctional mitochondria may drive age-related inflammation by helping switch on inflammatory genes, and blocking SLC25A1 reduced that activity. As people age, senescent cells accumulate in the body. These so-called “zombie” cells have stopped dividing but remain metabolically active, releasing inflammatory molecules that can contribute to persistent inflammation associated with frailty, cardio…

Phase 2 TRANQUILITY trial results presented by Mount Sinai investigator support further evaluation of pacibekitug in cardiovascular disease

A newly acquired Novartis drug cut signs of inflammation. The test will be whether that can improve people's heart health.

Nature Communications, Published online: 29 August 2026; doi:10.1038/s41467-026-77219-3 Atrial fibrillation involves systemic inflammatory activation that remodel the atrial endocardium. Here, the authors show that gut microbiota activate PLCy2 positive monocytes, promoting endothelial-to-mesenchymal transition and atrial fibrillation through a microbiota–monocyte–endocardial axis.

Senescence is a state in which stressed cells stop dividing but remain alive. New findings reveal that the underlying process unfolds in distinct stages that depend on the type of drug used, and show how a new class of drugs triggers inflammation.

Senescence is a state in which stressed cells stop dividing but remain alive. New findings reveal that the underlying process unfolds in distinct stages that depend on the type of drug used, and show how a new class of drugs triggers inflammation.

Scientists at Sanford Burnham Prebys Medical Discovery Institute, Mayo Clinic and their international collaborators published findings July 29, 2026, in Nature revealing a new connection between energy-producing mitochondria and chronic inflammation during aging. They also found that blocking a related gene reduced inflammation and promoted healthier aging in mice.

Scientists at Sanford Burnham Prebys Medical Discovery Institute, Mayo Clinic and their international collaborators published findings July 29, 2026, in Nature revealing a new connection between energy-producing mitochondria and chronic inflammation during aging. They also found that blocking a related gene reduced inflammation and promoted healthier aging in mice.

Scientists at Sanford Burnham Prebys Medical Discovery Institute, Mayo Clinic and their international collaborators published findings July 29, 2026, in Nature revealing a new connection between energy-producing mitochondria and chronic inflammation during aging. They also found that blocking a related gene reduced inflammation and promoted healthier aging in mice.

A heart attack can be treated successfully, blocked arteries can be reopened and standard blood tests can return to normal. Yet inside the body, part of the immune system may still behave as though the danger has not ended. A Swedish study has uncovered a possible reason for this hidden problem. Researchers at Linköping University […] The post Study Finds a Big Cause of Inflammation after Heart A…

Researchers have uncovered a previously unknown mechanism that helps aging cells drive the chronic inflammation linked to many age-related diseases.

A recent study revealed that periodontitis reprograms bone marrow neutrophils through a Chac2-driven glutathione metabolic pathway, promoting a highly inflammatory N1 state that fuels systemic inflammation.

Medicines known as GLP-1 receptor agonists have become widely known for helping people lose weight. Drugs such as semaglutide and tirzepatide can reduce appetite, help people eat less, and lead to substantial weight loss. Scientists are now discovering that these medicines may also improve health in ways that go beyond reducing body weight. A new […] The post Weight-Loss Drugs May Fight Harmful I…

Why Endpoint Protection Matters Immunology and inflammation (I&I) studies frequently rely on complex clinical assessments, composite disease activity scores, imaging evaluations, endoscopic findings, histopathology interpretations, and biomarker measurements to demonstrate treatment benefit. Unlike laboratory values that can be measured objectively, many efficacy endpoints in I&I trials depend on…

A Northwestern Medicine study has uncovered how chronic defects in muscle membrane repair can fuel harmful inflammation, according to the study published in JCI Insight. The post ‘Leaky’ Muscle Fibers Drive Immune Response in Muscular Dystrophy appeared first on News Center .

Inflammation is the body’s natural defense against infection and injury, but when it continues for months or years it can contribute to many serious illnesses. Chronic inflammation has been linked to inflammatory bowel disease, heart disease, type 2 diabetes, and some cancers. Because the gut plays a major role in controlling inflammation throughout the body, […] The post Scientists Turn Oysters …

A simple, non-invasive ultrasound treatment could one day help injured joints heal instead of remaining trapped in a cycle of damaging inflammation. Researchers at The University of Alabama in Huntsville found that continuous low-intensity ultrasound encouraged key immune cells called macrophages to shift from an inflammatory state toward one that supports tissue repair.