sleep-disorders

Live Science spoke with Dr. Emmanuel Mignot , director of the Stanford Center for Narcolepsy and co-winner of a coveted Lasker Award.

ObjectiveSleep disturbance and cognitive impairment are common in depression. Trazodone is often used for sleep problems and may improve cognition by modifying sleep architecture. However, its effects on specific polysomnography-derived sleep stages remain unclear. This systematic review and exploratory meta-analysis aimed to investigate trazodone’s effects on sleep architecture in patients with …

The Lasker Foundation has announced that UT Southwestern Medical Center sleep researcher Masashi Yanagisawa, M.D., Ph.D., is a recipient of the 2026 Albert Lasker Basic Medical Research Award for his discovery of orexin, a brain peptide that maintains wakefulness, and demonstration that the absence of its action is responsible for narcolepsy, a profound disorder of sleep.

Post-traumatic stress disorder (PTSD) is characterized by symptoms including hypervigilance, intrusive memories, and sleep disturbance. Insomnia and nightmares are among the most common and clinically important sleep-related symptoms in PTSD, yet effective and well-tolerated pharmacotherapies remain limited. Suvorexant, a dual orexin receptor antagonist (DORA) approved for insomnia, represents a …

BackgroundInsomnia and sleep disturbances are highly prevalent among healthcare professionals and pose risks to patient safety. Brain Dynamic Audio Stimulation (BDAS) is a non-invasive, open-loop auditory intervention intended to facilitate sleep initiation. This single-arm pilot feasibility study examined the feasibility and preliminary signal of a 14-day BDAS intervention in healthcare professi…

This is a narrative review aiming to summarize the latest research progress of orexin receptor antagonists in insomnia treatment. To review the latest research progress on orexin receptor antagonists in the treatment of sleep disorders and explore their potential in terms of drug safety, efficacy, addiction risk, and the treatment of insomnia comorbid with psychiatric and neurological disorders. …

The Food and Drug Administration just greenlit a medication called Orzeyful for the treatment of narcolepsy type 1 in adults. The condition is caused by the loss of brain cells that produce orexin, a chemical important for regulating the sleep-wake cycle

BackgroundThe relationship between sleep disorders and psychiatric disorders has been extensively studied in epidemiological research. However, whether specific sleep-related traits are associated with psychiatric disorders through potential causal mechanisms remains incompletely understood.MethodsThis study employed a two-sample Mendelian randomization (MR) analysis method to investigate potenti…

Poor sleep can affect almost every part of the body, including the hormones that keep us healthy. Researchers are increasingly finding that sleep disorders and hormone disorders often occur together. A new Brazilian study suggests that one of the strongest links may be between hypothyroidism and obstructive sleep apnea. Hypothyroidism develops when the thyroid gland […] The post Hidden Thyroid Pr…

Obstructive sleep apnea may affect more than the airway. By combining polysomnography with retinal imaging, we examined whether apnea severity is associated with retinal vascular fractal dimension and whether diabetes modifies this relationship.

According to a study conducted in Brazil by researchers at the Federal University of São Paulo (UNIFESP) with participants from the São Paulo Epidemiological Sleep Study (EPISONO 2018), people with hypothyroidism experience a higher frequency and severity of obstructive sleep apnea (OSA).

Anxiety and depressive disorders impose a heavy global burden. Although sleep disturbances have traditionally been regarded as secondary symptoms of these conditions, converging evidence now implicates circadian rhythm disruption as a core pathophysiological mechanism rather than a mere epiphenomenon. This review systematically explores the circadian system and constructs an integrated framework …

Insomnia disorder is one of the most common sleep disorders and is traditionally conceptualized in terms of hyperarousal, altered sleep homeostasis, and cognitive-behavioral perpetuating factors. The two-process model of sleep regulation indicates that sleep initiation and maintenance depend not only on homeostatic sleep pressure but also on circadian phase, amplitude, and stability. Evidence sug…

A rapid and accurate blood test has been developed that can measure melatonin in the blood in extremely small amounts. The method could open new possibilities, including sleep disorders, mental disorders and metabolic disorders. But the researchers emphasise that the clinical work has only just begun.

Many people think of snoring as little more than an annoyance, but for some people it may be a sign of a serious medical condition called obstructive sleep apnea. In this disorder, the muscles in the throat relax repeatedly during sleep, causing the airway to narrow or close. Breathing stops for short periods before the […] The post Sleep Apnea Linked to Poor Memory and Greater Dementia Risk appe…

ObjectiveSleep disorders represent a serious global health challenge. However, the role of major environmental exposures, such as high-altitude hypoxia, and how they modify the influence of established risk factors across populations with differing susceptibility, remains poorly understood. This study aims to investigate the association between metabolic markers and sleep disorders under various …

ObjectiveThis study aims to comprehensively analyze and evaluate the efficacy and safety of daridorexant in treating insomnia.MethodsThis study conducted a systematic search across 7 electronic databases: PubMed, Web of Science, Cochrane Library, Embase, ClinicalTrials.gov, Scopus and the World Health Organization International Clinical Trials Registry Platform [http://www.who.int/ictrp/search/en…

Although pharmacological treatments for insomnia remain widely prescribed, their long-term use is constrained by risks of tolerance, dependence, and residual daytime effects. This has prompted growing interest in non-pharmacological interventions that target insomnia’s underlying mechanisms. This narrative review examines five physical factor therapies for insomnia: auditory stimulation, photothe…

This JMCR case highlights a dramatic shift from mild obstructive sleep apnea at sea level to severe central sleep apnea at high altitude, refractory to CPAP and acetazolamide but successfully treated with CPAP plus supplemental oxygen.