Nature Cell Biology

Nature Cell Biology, Published online: 22 June 2026; doi:10.1038/s41556-026-02023-6 Author Correction: Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing

Nature Cell Biology, Published online: 22 June 2026; doi:10.1038/s41556-026-01984-y Bae et al. identify MED4 as a regulator of tumour dormancy from a genome-wide CRISPR screen, and show that loss of MED4 alters the enhancer landscape and induces extracellular matrix remodelling to drive metastatic relapse in breast cancer.

Nature Cell Biology, Published online: 22 June 2026; doi:10.1038/s41556-026-01977-x Metastatic relapse can occur long after dissemination, suggesting that dormant tumour cells retain the capacity to eventually ‘reawaken’. A study now shows that loss of MED4 reshapes enhancers, creating a primed, plastic state that enables desmoplastic niche formation and sensing, ultimately facilitating metastati…

Nature Cell Biology, Published online: 19 June 2026; doi:10.1038/s41556-026-01970-4 Nguyen et al. show that accumulation of dimethylarginine in lysosomes in disease models is associated with lipotoxicity and lipid droplet abundance.

Nature Cell Biology, Published online: 17 June 2026; doi:10.1038/s41556-026-02001-y Author Correction: Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain

Nature Cell Biology, Published online: 16 June 2026; doi:10.1038/s41556-026-02011-w Author Correction: Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution

Nature Cell Biology, Published online: 16 June 2026; doi:10.1038/s41556-026-02017-4 Author Correction: MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains

Nature Cell Biology, Published online: 15 June 2026; doi:10.1038/s41556-026-01990-0 Spatial profiling in bladder cancer

Nature Cell Biology, Published online: 15 June 2026; doi:10.1038/s41556-026-01994-w A platform to study pacemaker

Nature Cell Biology, Published online: 15 June 2026; doi:10.1038/s41556-026-01995-9 Starving and crowded in quiescence

Nature Cell Biology, Published online: 15 June 2026; doi:10.1038/s41556-026-01997-7 Author Correction: BRIT1/MCPH1 links chromatin remodelling to DNA damage response

Nature Cell Biology, Published online: 15 June 2026; doi:10.1038/s41556-026-01991-z Diao, Zou et al. demonstrate that activation of the integrated stress response drives lineage dedifferentiation and tumour progression in lung adenocarcinoma, associated with aberrant mitochondrial function and metabolic fitness.

Nature Cell Biology, Published online: 12 June 2026; doi:10.1038/s41556-026-01980-2 Bassot, Violy, Gorka, Cigalotto and colleagues identify ERO1a as a mitochondria-associated membrane protein that regulates calcium flux and mitochondria bioenergetics, which may be potentially targeted to inhibit glioblastoma growth in vivo.

Nature Cell Biology, Published online: 12 June 2026; doi:10.1038/s41556-026-01975-z This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and academic journey as an LGBTQIA+ immigrant.

Nature Cell Biology, Published online: 11 June 2026; doi:10.1038/s41556-026-02000-z Publisher Correction: Epigenetic programming by H3K23ac defines lineage fate of Meg3 + haematopoietic stem cells and drives immune ageing

Nature Cell Biology, Published online: 11 June 2026; doi:10.1038/s41556-026-01986-w Zollo et al. examine DRP1 behaviour at mitochondria: DRP1 diffuses along mitochondria in helical-like patterns influenced by MID49/MID51, scanning the organelle surface and stalling at preconstricted fission sites.

Nature Cell Biology, Published online: 11 June 2026; doi:10.1038/s41556-026-01985-x Wang, Liang and colleagues show that the TEAD1 transcription factor can organize micrometre-sized nuclear biomolecular condensates independently of active transcription. TEAD1 condensates may act as depots for excess TEAD1.

Nature Cell Biology, Published online: 11 June 2026; doi:10.1038/s41556-026-01993-x This Perspective highlights the use of current proteomics technologies in defining stage-specific reprogramming events to understand reproductive ageing, improve oocyte quality, and refine the outcomes of assisted reproductive technology (ART).

Nature Cell Biology, Published online: 10 June 2026; doi:10.1038/s41556-026-01965-1 De Belly et al. show Rac induces membrane-tension-mediated mTORC2 activation to stimulate long-range Rho activation. Meanwhile, Rho-mediated contractility and blebbing at the opposite side of the cell may lead to PI3K-dependent Rac activation.

Nature Cell Biology, Published online: 10 June 2026; doi:10.1038/s41556-026-01974-0 Oshio, Shiiba and colleagues show that HMOX2, which catalyses haem degradation, supplies haem-derived iron to mitochondria at ER–mitochondria contact sites in a process mediated by the mitochondrial ubiquitin ligase MITOL, also known as MARCH5/MARCHF5.