Frontiers in Neuroscience | Neurodegeneration section | New and Recent Articles

BackgroundCognitive impairment affecting memory and learning processes is a common non-motor feature of Parkinson’s disease (PD) and contributes substantially to functional decline and a reduced quality of life. Transcranial direct current stimulation (tDCS) has emerged as a potentially beneficial non-invasive neuromodulation technique capable of modulating cortical plasticity and enhancing cogni…

IntroductionEarly-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) may differ in large-scale network organization. We compared multimodal MRI markers of diagnosis-age-defined Alzheimer’s phenotypes.MethodsAlzheimer’s Disease Neuroimaging Initiative participants were classified by age at first recorded mild cognitive impairment or Alzheimer’s disease diagnosis: <65 years …

BackgroundMetabolic reprogramming in glial cells is increasingly recognized as a pivotal factor in the pathogenesis of AD. While both the pentose phosphate pathway (PPP), a crucial metabolic route for redox balance and biosynthesis, and astrocyte reactivity are implicated in AD, their integrated molecular interaction between processes remains largely uncharted.MethodsWe employed an integrated mul…

ObjectivesWith the global aging population, Alzheimer’s disease (AD) poses a major health challenge. The diffusion tensor image (DTI) analysis along the perivascular space (DTI-ALPS) index has emerged as a noninvasive imaging marker that indirectly reflects glymphatic function. However, its alterations in AD and their associations with cognitive impairment remain incompletely understood. This stu…

Although physical activity is consistently associated with lower risks of cognitive decline, dementia, and Parkinson’s disease, most exercise research in neurodegeneration still defines exposure by dose-based variables such as duration, intensity, frequency, step count, and cardiorespiratory fitness. This framework is useful for public-health guidance but biologically incomplete for progressive p…

Variation in the microtubule-binding protein tau is causally implicated in numerous neurodegenerative diseases, including Alzheimer’s disease. However, the mechanisms by which such variation results in disease are not well understood. The JNPL3(P301L) mouse model mimics the effects of the P301L mutation on human tau associated with frontotemporal dementia. As previously reported, phospho-tau aggr…

IntroductionWhile gene set enrichment analysis (GSEA) framework is widely used on transcriptomics or proteomics data, its applications beyond “omics” data has not been extensively explored. Its principal nature enables it to apply to any dataset where variables can be rationally sorted into categories, or sets. This study demonstrates a novel application of GSEA outside of its traditional use by …

Intracranial hemorrhage is a devastating neurological condition associated with high mortality and limited therapeutic options beyond surgical management. Increasing evidence identifies iron released from hemoglobin degradation as a central mediator of secondary brain injury and a critical trigger for chronic neurodegenerative processes that persist long after the acute hemorrhagic event across h…

BackgroundPrion diseases are rare, transmissible, and invariably fatal neurodegenerative disorders caused by the conformational conversion of cellular prion protein (PrPC) into its pathogenic isoform (PrPSc). Despite decades of research, no licensed disease-modifying therapies are currently available. This reflects the rapid clinical course of these disorders, the difficulty of early diagnosis, a…

Metabolic dysfunction-Associated Steatotic liver disease (MASLD) is one of the most common systemic diseases causing chronic liver diseases. Current evidence indicates that cognitive-related deficits occur frequently in MASLD, causing significant impacts on patients and their families, and even possibly increasing the economic and psychological burdens on healthcare, productivity, and nursing sta…

ObjectiveThis study aimed to investigate the association between deep medullary veins (DMVs) score and comorbid idiopathic normal pressure hydrocephalus (iNPH) in patients with arteriolosclerotic cerebral small vessel disease (aCSVD), and to analyze its role as an independent associated factor.MethodsA total of 80 patients with aCSVD, 40 patients with arteriolosclerotic cerebral small vessel dise…

Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide classically implicated in the regulation of energy homeostasis, sleep–wake cycle and motivated behaviors. Over the last 30 years, an increasing amount of evidence has revealed a complex, non-linear role in memory processing. In this mini-review, we summarize experimental findings on the multifaceted influence of MCH on memory, hig…

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by debilitating motor impairment, cognitive decline, and a substantial reduction in patient quality of life. While pharmacological treatments and standard physiotherapy provide essential symptomatic relief, they often offer only transient benefits. Consequently, there is growing interest in non-pharmacological inte…

The development of Alzheimer disease (AD) involves a cluster of pathogenic processes, including amyloid-beta (Aβ) deposition, tau-mediated neurodegeneration, chronic neuroinflammation, oxidative stress (OS), metabolic dysregulation, and disruption of circadian rhythms. Nuclear hormone receptor, Retinoic Acid-Related Orphan Receptor Alpha (RORα) was shown to regulate multiple neuroprotective pathw…