therapeutics

Endometrial dysfunction represents a central pathological factor underlying recurrent implantation failure and infertility. This review provides a comprehensive synthesis of the physiological basis of endometrial function, the pathological factors compromising its integrity, and the impact of these abnormalities on embryo implantation. Key pathogenic drivers, including cellular senescence, chroni…

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease for which disease-modifying therapies remain limited. Despite extensive efforts targeting amyloid-β and tau, these approaches have not translated into clear clinical benefit, underscoring the need for a more integrated understanding of AD pathogenesis. This narrative review summarizes recent advances in the molecular mechanisms u…

Researchers from ETH Zurich have developed a molecular switch that is controlled by light. It wakes lung cancer cells up from a protective dormant state so that they are more accessible for treatment. Tumour cells can lapse into a sleep-like state and thereby evade the destructive effect of cancer d...

The metabolism of cancer cells is reprogrammed toward aerobic glycolysis (the Warburg effect), which stimulates tumor growth. Phosphofructokinase (PFK) and its isoforms, PFKP, PFKM, and PFKL, are highly conserved central glycolytic controllers and a potential therapeutic intervention. This review discusses the complex functions of PFK in tumor biology, including its roles in regulating proliferat…

This review synthesizes current evidence on autonomic nervous system (ANS) dysfunction in irritable bowel syndrome (IBS). Patients with IBS often exhibit sympathovagal imbalance–reduced vagal tone with relative sympathetic hyperactivity–which correlates with symptom severity and shows subtype specificity. The ANS orchestrates bidirectional brain–gut communication via interactions with psychosocia…

This review summarizes the mechanistic and therapeutic relevance of Signal Transducer and Activator of Transcription 3 (STAT3) in systemic lupus erythematosus (SLE) and lupus nephritis (LN), with an emphasis on how structural information can inform drug development. STAT3 integrates cytokine- and growth factor-driven JAK-STAT signaling, supports pathological T cell differentiation, B cell activat…

This post highlights the translational relevance of photobiomodulation (PBM) as a complementary therapeutic strategy capable of modulating inflammation, tissue repair, mitochondrial activity, and immunological pathways through measurable biophysical mechanisms.

Targeted drug delivery to the brain has long been hindered by the blood-brain barrier, a protective layer that prevents many therapeutic agents from reaching their intended targets. For patients with serious neurological disorders, this challenge can significantly reduce access to potentially effective treatments and limit therapeutic outcomes.  In this episode of Curing with Sound, we ...

Parkinson’s disease is a serious brain disorder that slowly affects movement over time. Millions of people around the world live with this condition. It can cause shaking, stiffness, slow movement, balance problems, and trouble walking. As the disease progresses, even simple daily tasks such as getting dressed, writing, or eating can become difficult. Doctors currently […] The post New brain stim…

A survey found that more than 60 percent of respondents “strongly support” making psychedelics easier to study, reflecting a growing consensus that some could have therapeutic use

A Field in Motion: Growing Opportunity for Therapeutic Innovation For biopharma sponsors, scientific clarity, measurable outcomes, and ease of regulatory validation are important factors to consider when developing new therapies. As the industry focus on precision medicine and orphan drug innovation continues to grow, rare endocrine system disorders emerge as a strategically important area for [……

Immunogenic cell death (ICD) is a distinct mode of regulated cell death capable of activating adaptive immune responses against tumor antigens, offering great promise for cancer immunotherapy. However, immune-excluded or “cold” tumors, characterized by poor immune infiltration and limited responsiveness to conventional immunotherapies, remain a major clinical challenge. ICD induction has emerged …

Acta Pharmacologica Sinica, Published online: 04 May 2026; doi:10.1038/s41401-026-01794-w Nanoparticles for autoimmune diseases: advancing diagnostics and therapeutic solutions

Despite reducing amyloid plaques, antibody treatments for Alzheimer's fail to improve cognition, highlighting critical gaps in current therapeutic approaches.

Our latest publication in Wiley Advanced Science: “Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice” is now online. This is the first in-vivo demonstration of our wireless, minimally invasive platform for remote magnetomechanical neuromodulation. Using biocompatible magnetic nanodiscs and externally applied …

Capital accelerates commercialization of WashU discoveries into life-changing diagnostics, therapeutics and medical devices

A new study has demonstrated that focused ultrasound alone could help treat Alzheimer’s disease, marking a potential breakthrough that doesn’t require medication.

New industry support enables the team to expand their search and validation of diagnostic biomarkers to shed light on asthma with thus far unexplained causes and improve therapy

A treatment for depression designed as a game for patients will be assessed in a clinical trial conducted by a university psychology lab and funded by National Institutes of Health.

By Ritchi Morris, Ph.D., H.M.D., D.N., R.H. Professional Member AANC There is a plethora of clinical and research data substantiating the extraordinary therapeutic efficacy of D-L Phenylalanine (DLPA). Abstract In this day and age the incidence of severe acute and chronic pain has been burgeoning progressively. This trend has spanned a multi-million dollar industry of pain […] The post DLPA: Natu…