neuroinflammation

Understanding ‘Brain Fog’ Defining and Impacting  ‘Brain Fog’ with Nutrition Chronic neuroinflammation is implicated in the propagation of “brain fog”, a colloquial term used to describe a heterogeneous set of cognitive issues, including brain-based fatigue, effortful cognition, poor focus, and forgetfulness. Complaints of brain fog and other cognitive inefficiencies have increased in frequency i…

BackgroundEpi-transcriptomic modifications, particularly N4-acetylcytidine (ac4C), and chronic neuroinflammation have emerged as pivotal players in the pathogenesis of Parkinson’s disease (PD). However, the specific molecular co-expression patterns linking ac4C RNA modification to neuronal inflammatory responses remains largely uncharted.ObjectiveThis study aimed to decode the ac4C-neuroinflammat…

AimAquaporin-4 (AQP4), predominantly expressed in astrocytes, has been implicated in neuroinflammation through the amplification of cytokine and chemokine production. Goreisan (GRS), a traditional Japanese herbal medicine, modulates AQP4-related water homeostasis. However, its effects on AQP4-associated inflammatory processes remain unclear. This study aimed to elucidate the anti-inflammatory eff…

Nature Communications, Published online: 29 August 2026; doi:10.1038/s41467-026-76159-2 This study identifies SerpinOLs, injury-responsive oligodendrocytes producing SERPINA3N, as a common cell state in disease and aging, which amplify neuroinflammation and glial activation beyond myelin-related functions in mice.

Acta Pharmacologica Sinica, Published online: 24 August 2026; doi:10.1038/s41401-026-01915-5 Microglial TLR7 contributes to traumatic brain injury-induced neuroinflammation in mice

A systematic review of animal research suggests that caffeine can reduce anxiety and depressive-like behaviors by acting as a brake on the brain's immune system and lowering neuroinflammation.

Scientific Reports, Published online: 21 August 2026; doi:10.1038/s41598-026-50683-z Sulforaphane-induced NRF2 activation improves spatial memory and modulates neuroinflammation in a streptozotocin-induced rat model of sporadic Alzheimer’s disease

Conditions such as long COVID-19, Alzheimer’s disease and meningitis can damage the line of communication between your brain and your muscles.

BackgroundEmerging evidence indicates that the neuroprotective effects of Astragalus polysaccharides (APS), an extract compound and bioactive constituent derived from traditional Chinese herbs, may be relevant to an effective prescription for delaying progression of Alzheimer’s disease (AD), yet the underlying mechanisms remain to be fully elucidated. This study aimed to investigate the therapeut…

S100A6 (calcyclin) is a multifunctional Ca2+/Zn2+-binding protein of the S100 family, widely expressed in neurons and glia with a developmentally regulated and cell-type-specific pattern. This review synthesizes current knowledge on its roles in the nervous system. We detail its complex interactome, which includes cytoskeletal regulators, molecular chaperones, nuclear transport proteins, and cell…

dc.title: Nanomedicine Strategies to Ameliorate Neuroinflammation and Prevent Secondary Neural Tissue Damage dc.description.abstract: The burden of neurological disease remains a global issue continually rising requiring the need for effective therapeutics to disrupt disease progression. Across neurological diseases, neuroinflammation presents as shared a pathophysiological hallmark presenting a …

Nature Communications, Published online: 08 August 2026; doi:10.1038/s41467-026-75862-4 Strategies to modulate neuroinflammation have broad therapeutic potential. Here, the authors develop siMETTL3-hNVs, nanovesicles carrying siRNA targeting METTL3, and show they can reduce neuroinflammation in vitro and in vivo.

IntroductionInflammatory processes contribute significantly to the pathophysiology of depression. Although the melanocortin system is well known to regulate inflammation, the specific contribution of melanocortin 1 receptor (MC1R) and its endogenous ligand, α-melanocyte-stimulating hormone (α-MSH), to inflammation-associated depression remains unclear.MethodsSystemic lipopolysaccharide (LPS) admi…